Skip to main content

Table 4 Single SNP association results comparing all AMD subtypes with normal subjects

From: Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration

   

Expanded sibpair cohort

Greeks

 

NHS/HPFS

Meta-analysis

SNP

Gene

Allele

Odds ratio

(95% CI)

p-Value

Odds ratio

(95% CI)

p-Value

Odds ratio

(95% CI)

p-Value

Odds ratio

(95% CI)

p-Value

rs2189480

VDR

A

1.801 (1.069-3.035)

0.0270

1.199 (0.846-1.700)

0.3080

0.903 (0.766-1.064)

0.2213

0.997 (0.865-1.151)

0.9710

rs2296241

CYP24A1

C

1.345 (0.829-2.182)

0.2294

1.185 (0.842-1.668)

0.3306

  

1.036 (0.814-1.319)

0.7711

rs4809960

CYP24A1

G

0.983 (0.567-1.703)

0.9515

1.027 (0.690-1.527)

0.8967

  

1.116 (0.843-1.477)

0.4425

rs4809959

CYP24A1

T

1.238 (0.770-1.989)

0.3781

1.058 (0.761-1.470)

0.7369

  

1.124 (0.885-1.427)

0.3391

rs2181874

CYP24A1

T

0.871 (0.501-1.515)

0.6242

0.687 (0.481-0.983)

0.0400

0.989 (0.812-1.204)

0.9116

0.894 (0.763-1.046)

0.1629

rs6068816

CYP24A1

A

2.081 (0.945-4.586)

0.0690

1.141 (0.695-1.875)

0.6012

  

1.243 (0.851-1.817)

0.2600

rs6091828

CYP24A1

A

1.338 (0.281-6.382)

0.7148

0.536 (0.206-1.393)

0.2006

  

0.745 (0.356-1.560)

0.4352

rs6127119

CYP24A1

A

1.284 (0.724-2.274)

0.3924

1.245 (0.831-1.865)

0.2881

  

1.257 (0.937-1.688)

0.1275

c.990 + 189

G > A

CYP24A1

A

0.887 (0.138-5.700)

0.8993

1.699 (0.323-8.925)

0.5312

  

1.123 (0.347-3.630)

0.8464

rs6127118

CYP24A1

T

1.297 (0.725-2.319)

0.3816

1.274 (0.845-1.921)

0.2471

1.050 (0.864-1.276)

0.6230

1.111 (0.946-1.305)

0.1995

c.990 + 222-

223 ins99

CYP24A1

ins

1.341 (0.744-2.417)

0.3288

1.297 (0.867-1.939)

0.2055

1.086 (0.874-1.350)

0.4564

1.145 (0.963-1.363)

0.1258

rs2296239

CYP24A1

A

1.457 (0.819-2.590)

0.2000

1.529 (0.976-2.396)

0.0638

1.205 (0.993-1.463)

0.0584

1.217 (1.035-1.430)

0.0174

rs2274130

CYP24A1

C

1.751 (0.975-3.147)

0.0610

1.512 (0.970-2.358)

0.0679

1.255 (1.029-1.529)

0.0247

1.248 (1.059-1.47)

0.0082

rs1570670

CYP24A1

C

1.790 (0.981-3.267)

0.0579

1.512 (0.970-2.358)

0.0679

1.195 (0.984-1.452)

0.0725

1.220 (1.037-1.436)

0.0165

rs1977297

CYP24A1

A

0.725 (0.293-1.791)

0.4856

1.142 (0.621-2.101)

0.6693

  

1.009 (0.643-1.582)

0.9694

rs1570669

CYP24A1

C

1.153 (0.690-1.927)

0.5875

1.287 (0.894-1.852)

0.1753

1.309 (1.104-1.551)

0.0019

1.285 (1.116-1.478)

0.0005

rs927650

CYP24A1

A

0.914 (0.596-1.402)

0.6804

1.468 (1.048-2.056)

0.0257

0.853 (0.728-0.999)

0.0487

0.969 (0.852-1.102)

0.6316

rs2762934

CYP24A1

T

0.743 (0.367-1.502)

0.4082

1.067 (0.704-1.619)

0.7595

0.930 (0.754-1.148)

0.5016

0.949 (0.798-1.130)

0.5574

rs4809957

CYP24A1

C

1.475 (0.822-2.644)

0.1925

1.462 (0.943-2.268)

0.0896

1.191 (0.981-1.445)

0.0772

1.196 (1.017-1.405)

0.0300

rs6022987

CYP24A1

G

0.755 (0.427-1.336)

0.3347

1.169 (0.804-1.699)

0.4136

  

1.109 (0.845-1.456)

0.4567

rs11907350

CYP24A1

T

0.363 (0.066-2.000)

0.2445

1.296 (0.438-3.836)

0.6397

1.246 (0.829-1.872)

0.2896

1.111 (0.772-1.598)

0.5711

  1. Abbreviation: CI, confidence interval; SNP, single nucleotide polymorphism.
Back to article page

Human Genomics

ISSN: 1479-7364