Figure 5
From: Trick or treat: The effect of placebo on the power of pharmacogenetic association studies
The effect of haplotype analysis versus one single nucleotide polymorphism (SNP) analysis on the power of detecting an association between the markers and the response to the drug. The results are based on 100 simulations for marker analysis and 1,000 simulations for haplotype analysis. Markers (M) were chosen according to frequency categories. The estimated power is shown for the causative SNP (-x-), haplotype analysis (-■-) and single marker (-▲-) analysis. (a) M = 3, genotype relative risk (GRR) = 3, f2 = 0.6, f0 = 0.2; (b) M = 5, GRR = 3, f2 = 0.6, f0 = 0.2; (c) M = 5, GRR = 3, f2 = 0.8, f0 = 0.266; (d) M = 5, GRR = 4, f2 = 0.8, f0 = 0.2; (e) M = 3, GRR = 4, f2 = 0.8, f0 = 0.2; (f) M = 5, GRR = 4, f2 = 0.8, f0 = 0.2.