Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: Study design, methods and feasibility

Table 6 Group 3: Markers and alleles showing significant allele frequencies among NPC cases plus IgA⁺ cases and IgA^- subjects.

cM	Locus	Individuals#			Allele freq(%)			Dominant			Recessive
		Allele	NPC	IgA-	NPC+IgA+		IgA-	OR	pvalue	95% CI	OR	pvalue	95% CI
37.64	D4S2950	137	604	319	15.0	<	18.5	0.69	0.01	0.51-0.93	1.06	0.88	0.50-2.26
40.14	D4S190	170	627	332	24.1	>	18.7	1.50	0.005	1.13-1.99	1.99	0.07	0.96-4.14
40.75	D4S174	202	616	331	27.4	<	32.6	0.79	0.10	0.60-1.05	0.46	0.001	0.28-0.74
40.75	D4S174	204	616	331	11.5	>	8.5	1.45	0.04	1.02-2.08	3.17	0.15	0.67-15.0
43.27	D4S3357	275	611	326	21.4	<	24.8	0.72	0.02	0.55-0.96	0.95	0.87	0.51-1.75
44.09	D4S1627	218	625	335	31.8	<	38.1	0.76	0.05	0.58-1.0	0.57	0.007	0.38-0.86
44.48	D4S3241	136	611	325	13.4	>	8.9	1.63	0.007	1.14-2.31	1.85	0.30	0.58-5.89
45.84	D4S1536	284	615	327	34.5	<	40.7	0.78	0.09	0.59-1.04	0.55	0.004	0.37-0.83
46.25	D4S401	213	628	333	10.8	<	11.1	1.09	0.63	0.77-1.53	0.33	0.05	0.11-1.00
52.72	D4S3255	189	614	328	8.5	>	6.1	1.50	0.05	1.0-2.25	3.18	0.30	0.36-28.0
52.95	D4S1577	143	624	332	35.8	<	41.6	0.72	0.02	0.54-0.95	0.67	0.03	0.46-0.96
53.03	D4S3347	213	623	332	34.3	>	29.5	1.58	0.001	1.20-2.08	1.02	0.93	0.66-1.58
53.03	D4S3347	217	623	332	45.2	<	50.0	0.90	0.48	0.66-1.22	0.62	0.004	0.45-0.86
54.86	D4S1594	266	620	330	66.5	>	64.2	1.57	0.03	1.04-2.38	1.03	0.86	0.78-1.35

Abbreviations: CI, confidence interval; cM, centimorgan; IgA, immunoglobulin A; OR, odds ratio.

ISSN: 1479-7364