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Table 4 Amino acid sequence homology between human IL proteins, as well as closely related cytokines.

From: Evolutionary divergence and functions of the human interleukin (IL) gene family

IL1-like

          
 

IL1A

IL1B

IL1RN

IL18

IL1F5

IL1F6

IL1F7

IL1F8

IL1F9

IL1F10

IL1B

23.3%

(39.5%)

         

IL1RN

14.5%

(24.8%)

19.4%

(28.5%)

        

IL18

13.7%

(25.8%)

13.2%

(28.6%)

15.9%

(28.8%)

       

IL1F5

12.0%

(19.7%)

15.4%

(23.3%)

40.1%

(48.7%)

11.4%

(20.4%)

      

IL1F6

10.6%

(15.2%)

15.8%

(22.6%)

24.4%

(38.1%)

18.3%

(31.7%)

29.1%

(42.3%)

     

IL1F7

14.2%

(26.1%)

21.2%

(35.2%)

21.2%

(37.2%)

17.6%

(32.2%)

24.4%

(34.7%)

25.0%

(37.7%)

    

IL1F8

9.1%

(19.3%)

12.4%

(18.6%)

14.5%

(22.8%)

7.7%

(16.5%)

14.6%

(25.9%)

24.5%

(35.5%)

18.6%

(32.5%)

   

IL1F9

14.0%

(21.7%)

11.8%

(20.6%)

22.7%

(35.0%)

21.0%

(35.7%)

26.1%

(39.4%)

51.4%

(64.8%)

26.9%

(41.6%)

23.4%

(36.8%)

  

IL1F10

11.7%

(20.9%)

12.4%

(22.0%)

33.3%

(44.8%)

14.4%

(32.7%)

39.3%

(54.6%)

24.9%

(39.9%)

21.2%

(35.8%)

12.3%

(21.1%)

27.4%

(42.5%)

 

IL33

12.7%

(21.8%)

16.1%

(29.8%)

17.7%

(28.0%)

12.8%

(24.7%)

13.4%

(20.5%)

13.6%

(23.0%)

7.3%

(12.7%)

5.6%

(11.5%)

4.0%

(6.1%)

4.5%

(8.9%)

γ-chain utilising

 

IL2

IL7

IL9

IL15

IL21

     

IL7

5.7%

(10.4%)

         

IL9

16.9%

(29.2%)

17.6%

(28.0%)

        

IL15

18.2%

(33.7%)

16.7%

(27.3%)

17.3%

(28.1%)

       

IL21

19.5%

(33.5%)

15.0%

(29.2%)

17.9%

(30.0%)

21.9%

(38.8%)

      

TSPL

5.8%

(11.6%)

19.5%

(31.0%)

18.6%

(29.5%)

10.5%

(16.9%)

17.7%

(28.3%)

     

IL4-like

          
 

IL3

IL4

IL5

IL13

      

IL4

22.1%

(30.4%)

         

IL5

23.5%

(34.2%)

21.4%

(33.0%)

        

IL13

24.7%

(38.7%)

23.6%

(32.5%)

23.9%

(35.2%)

       

CSF2

22.0%

(32.8%)

24.4%

(35.1%)

25.6%

(41.1%)

21.5%

(34.9%)

      

IL6/12-like

          
 

IL6

IL11

IL12A

IL23A

IL27A

IL31

CLCF1

CNTF

  

IL11

20.0%

(35.1%)

         

IL12A

16.4%

(28.9%)

3.5%

(5.4%)

        

IL23A

19.7%

(30.8%)

19.8%

(25.5%)

18.9%

(29.4%)

       

IL27A

19.8%

(31.7%)

22.1%

(32.0%)

4.4%

(5.8%)

16.2%

(25.6%)

      

IL31

15.7%

(28.8%)

10.8%

(16.0%)

7.6%

(15.2%)

21.0%

(32.9%)

12.7%

(18.0%)

     

CLCF1

17.0%

(29.3%)

21.5%

(28.5%)

15.0%

(23.9%)

13.3%

(20.1%)

20.3%

(29.7%)

10.2%

(16.4%)

    

CNTF

15.6%

(28.1%)

8.7%

(10.7%)

11.2%

(20.0%)

12.5%

(24.9%)

18.9%

(30.0%)

13.9%

(22.3%)

20.1%

(29.7%)

   

CTF1

3.8%

(8.5%)

24.4%

(30.7%)

3.6%

(5.6%)

16.3%

(21.9%)

5.1%

(8.1%)

12.3%

(19.0%)

21.8%

(33.3%)

20.7%

(33.2%)

  

IL10-like

          
 

IL10

IL19

IL20

IL22

IL24

     

IL19

17.0%

(37.5%)

         

IL20

25.7%

(45.0%)

38.5%

(57.7%)

        

IL22

21.7%

(36.9%)

18.9%

(35.4%)

20.2%

(36.0%)

       

IL24

18.3%

(37.2%)

23.7%

(41.2%)

26.8%

(45.5%)

23.3%

(36.1%)

      

IL26

25.0%

(47.8%)

21.8%

(37.9%)

19.6%

(35.7%)

20.5%

(35.0%)

20.7%

(37.6%)

     

IL28-like

          
 

IL28A

IL28B

        

IL28B

94.0%

(95.5%)

         

IL29

66.5%

(73.7%)

68.8%

(75.1%)

        

IL17-like

          
 

IL17A

IL17B

IL17C

IL17D

IL25

     

IL17B

25.9%

(37.6%)

         

IL17C

26.4%

(37.0%)

24.9%

(38.3%)

        

IL17D

20.3%

(24.5%)

26.1%

(35.2%)

22.3%

(27.5%)

       

IL25

25.0%

(40.0%)

18.3%

(27.2%)

26.3%

(35.7%)

21.2%

(30.3%)

      

IL17F

45.7%

(59.0%)

25.0%

(40.2%)

25.5%

(37.5%)

20.6%

(28.8%)

19.8%

(31.8%)

     
  1. Percentage identity and similarity (in parentheses) were determined using the EMBOSS Pairwise Alignment Algorithm www.ebi.ac.uk/Tools/emboss/align/ and non-redundant human protein sequences. The predominant, mature isoform sequences were used for proteins having multiple variants
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Human Genomics

ISSN: 1479-7364