Table 1 Genetically influenced metabolites. Significant genetic variant–metabolite associations at a genome-wide significance of p < 3.5 × 10–12 (= 5 × 10–8/14,342 features) are shown.
Feature (m/z, RT) | Lead SNP position* | EA, OA | EAF | Beta | Standard error | p value | Candidate genes |
|---|---|---|---|---|---|---|---|
m/z 394.8915, RT 68.1 | chr9:72,902,395 | G, A | 0.14 | − 0.49 | 0.063 | 4.94E−14 | ALDH1A1 |
m/z 640.3195, RT 278.2 | chr20:38,052,517 | G, T | 0.08 | − 1.23 | 0.167 | 7.35E−13 | RPRD1B |
|  | chr10:66,637,441 | A, G | 0.07 | − 0.69 | 0.090 | 1.56E−13 | CTNNA3 |
m/z 709.0644, RT 190.3 | chr8:47,661,411 | A, G | 0.07 | 0.93 | 0.128 | 1.80E−12 | SPIDR |
m/z 101.5811, RT 100.6 | chr10:98,377,943 | T, C | 0.46 | − 0.61 | 0.065 | 4.82E−19 | PYROXD2** |
m/z 161.1285, RT 106.1 (N6-Methyl-L-lysine) | chr10:98,377,943 | T, C | 0.46 | − 0.49 | 0.061 | 6.98E−15 | PYROXD2** |
m/z 162.1321, RT 106.9 (N6-Methyl-L-lysine) | chr10:98,377,943 | T, C | 0.46 | − 0.54 | 0.064 | 3.32E−16 | PYROXD2** |
m/z 175.1442, RT 104.5 (Ne,Ne dimethyllysine) | chr10:98,377,943 | T, C | 0.46 | − 0.55 | 0.056 | 6.20E−21 | PYROXD2** |
m/z 188.9574, RT 44.2 | chr12:66,599,541 | C, T | 0.06 | − 1.22 | 0.164 | 5.69E−13 | GRIP1 |
|  | chr15:88,215,350 | A, C | 0.15 | − 0.84 | 0.116 | 2.85E−12 | NTRK3 |
|  | chr21:14,901,801 | G, C | 0.13 | − 0.85 | 0.117 | 1.94E−12 | NRIP1 |
m/z 220.1777, RT 24 | chr16:7,273,260 | C, T | 0.08 | − 1.03 | 0.137 | 3.45E−13 | RBFOX1 |
m/z 269.0023, RT 125.5 (fenson) | chr4:40,241,127 | G, C | 0.06 | 0.47 | 0.061 | 9.20E−14 | RHOH |
m/z 283.2741, RT 27.6 | chr7:12,354,019 | G, A | 0.12 | 0.27 | 0.037 | 1.55E−12 | VWDE |
|  | chr7:72,362,534 | A, G | 0.07 | 0.35 | 0.047 | 3.02E−13 | CALN1 |
m/z 300.2167, RT 37.1 | chr2:210,210,185 | C, T | 0.31 | 0.68 | 0.077 | 5.62E−17 | ACADL** |
m/z 781.7483, RT 89.3 | chr8:3,674,391 | C, T | 0.11 | 0.73 | 0.093 | 2.29E−14 | CSMD1 |