Fig. 3From: Pharmacovariome scanning using whole pharmacogene resequencing coupled with deep computational analysis and machine learning for clinical pharmacogenomicsHomology modelling for three selected pharmacovariants in deep computational analysis. Close view of three damaging variants with potential influence on changing protein structure and functions in selected genes: A Wild type POLG protein, produced using 3IKM as the template, close view of Pro587. B Mutated POLG (p. Pro587Leu) protein model, produced using 3IKM as the template. C Wild type annexin A11 protein modelled using 6TU2 as the template, close view of Arg230. D Mutated annexin A11 protein (p. Arg230Cys) modelled using 6TU2 as the template. E Wild type EC 26 domain of cadherin-23 protein modelled using mouse cadherin-23 structure (5WJM) as the template, close view of Gly2771. F Mutated EC 26 domain of cadherin-23 protein (p. Gly2771Ser), modelled using mouse cadherin-23 structure (5WJM) as the templateBack to article page