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Fig. 1 | Human Genomics

Fig. 1

From: A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis

Fig. 1

Flowchart of the overall study design. We investigated the shared genetic architecture underlying sex hormone-binding globulin (SHBG) and rheumatoid arthritis (RA). We first quantified the genome-wide genetic correlation between SHBG and RA; we then estimated local genetic correlations by partitioning the genome into linkage-disequilibrium independent blocks. Next, we identified potential pleiotropic loci contributing to both traits and conducted functional annotation for these loci. We also performed fine-mapping and transcriptome-wide association analysis to provide biological insight. Finally, to make a causal inference, we conducted a bidirectional Mendelian randomization

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Human Genomics

ISSN: 1479-7364