Fig. 3
Cross-trait meta-analysis: BMI-adjusted sex hormone-binding globulin and rheumatoid arthritis (excluding MHC). Independent top-associated loci of sex hormone-binding globulin adjusted for BMI and rheumatoid arthritis were located in the inner and middle circles of the circular Manhattan plot, respectively. Results of cross-trait meta-analyses were listed in outer circles. Significant pleiotropic SNPs were presented by red spots, defined as variants with P SHBGadjBMI < 1 × 10–5, PRA < 1 × 10–5, and PCPASSOC < 5 × 10–8. Novel pleiotropic SNPs detected for SHBGadjBMI with RA were marked by a green spot, and defined as a significant pleiotropic SNP neither reached genome-wide significance in a single trait (5 × 10–8 < PSHBGadjBMI < 1 × 10–5, 5 × 10–8 < PRA < 1 × 10–5, and PCPASSOC < 5 × 10–8) nor in linkage-disequilibrium (LD) with previously identified SHBG- or RA-associated SNPs. MHC regions were excluded due to their complex LD pattern. Chr: chromosome; SHBGadjBMI: sex hormone-binding globulin adjusted for BMI. RA: rheumatoid arthritis