Table 1 Clinical phenotypes of congenital ichthyosis (CI) cohort

Hyperkeratosis (thick skin)

IV(15), HI(8), LI(3), EI(4), TTD(3), ARC(1), SLS(2)

100

Itch/Pruritus

IV(15), HI(8), LI(3), EI(4), TTD(3), ARC(1), SLS(1)

97.22

Skin microbial infection* (n = 18)

IV(9), HI(2), EI(1), TTD(2), SLS(1)

83.33

Erythroderma

IV(10), HI(8), LI(1), EI(4), TTD(2) SLS(1)

72.22

Respiratory comorbidities

IV(10), HI(3), EI(2), TTD(3), SLS(1)

52.78

Sepsis

IV(7), HI (6), LI(2), EI(1), TTD(3)

52.78

Collodion membrane at birth

IV(1), HI(8), LI(3)

33.33

Cardiomyopathy comorbidities

IV(4), HI (2), EI(2), TTD(3)

30.56

Blistering

HI(8), EI(2)

27.78

Loss of heat

HI(3), LI(1), EI(2)

16.67