From: FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction
Method | Sensitivity | Specificity | BACC | AUC-ROC |
---|---|---|---|---|
Experimental | 0.81 | 0.92 | 0.87 | 0.92 |
FiTMuSiC | 0.96 | 0.92 | 0.94 | 0.98 |
FATHMM | 1.00 | 0.00 | 0.50 | 0.79 |
PROVEAN | 0.96 | 0.77 | 0.87 | 0.87 |
DEOGEN2 | 1.00 | 0.23 | 0.62 | 0.93 |
PolyPhen-2 | 0.98 | 0.31 | 0.64 | 0.91 |
EVE | 0.94 | 0.92 | 0.93 | 0.98 |
Sequence UNET | 0.70 | 0.77 | 0.73 | 0.82 |
MutPred2 | 1.00 | 0.54 | 0.77 | 0.96 |
AlphaMissense | 0.98 | 0.92 | 0.95 | 0.99 |