Figure 2

Chromosome syntenic organisation imputed by the Multiple Genome Rearrangement Algorithm for preancestors (denoted with asterisks) of human, of cat and of mouse, and for the reconstructed common ancestor (A) of all three starting genomes (human, cat and mouse). The data consisted of 379 common markers grouped into 106 clusters shared across the three starting genomes (human, cat and mouse) derived using a distance threshold of G = 6. The length of each chromosome is proportional to its number of cluster segments. Each human chromosome (and its component cluster segment [boxed]) is assigned a unique colour. Each cluster segment is traversed by a diagonal line (top left to bottom right) to indicate relative order and orientation within the blocks. The number above each coloured block refers to the corresponding human chromosome homologue. Species chromosome designations are shown to the left. At the top of the figure, the phylogram indicates the number of rearrangements required to convert one genome into the other.