Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps

Table 2 Comparison of the Multiple Genome Rearrangement (MGR) algorithm-derived syntenies found in the common ancestors of the human-cat-mouse (HCM) and the human-cat-cow (HCC) datasets, with predicted syntenies based on comparative cytogenetic analyses (left-hand column⁸).

Predicted syntenies⁸	HCM G= 4	HCM G= 5	HCM G= 6	HCC G= 4	HCC G= 5	HCC G= 6
3 & 21	+,f	+	+	+	+	+
4 & 8p	+	+	+	n.c.a.	-	-
7a/16p	n.c.a.	n.c.a.	+	+	+	+
12 & 22a	+,f	+,f	+,f	-	-	-
12 & 22b	-	-	n.c.a.	n.c.a.	n.c.a.	n.c.a.
14 & 15	+,f	+	-	+	-	-
16q/19q	-	+	+	-	+	+
1p	+,f	+	+,f	+	+	+
1q	-	-	-	-	-	-
2p	+,f	+,f	+,f	+,f	+,f	+,f
2q	+	+	+	+	+	+,f
5	+,f	+,f	+,f	+,f	+	-
6	+	+	+	+	+	+
7b	+,f	-,f	+,f	+,f	+,f	+,f
8q	+	+	+	+	+	+
9	+	+	+	+	+	+
10p	+,f	+,f	+,f	+,f	+,f	+,f
10q	+,f	-	+,f	+,f	+,f	+,f
11	-	-	+,f	+	+	+
13	+,f	+,f	+,f	+	+	+,f
17	+	+	+	+	+	+
18	+	+,f	+,f	+	+	+
19p	+,f	+,f	+,f	+,f	+	+
20	+,f	+,f	+,f	+,f	+,f	+
X/f	+	+	+	+	+	+

MGR analyses were performed using the indicated distance threshold, G
'+' means synteny is intact in the ancestor, '-' means synteny is disrupted in the ancestor, ' + ,f ' means synteny is intact and fused to another chromosome in the ancestor. n.c.a. = no chromosome available, due to lack of shared markers defining that conserved segment.

ISSN: 1479-7364