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Table 3 Conserved markers, clusters and reversal distances computed with GRIMM-synteny and the Multiple Genome Rearrangement Algorithm analysis of comparative gene maps of 311 Type I gene homologues aligned between human (H), cat (Ct) and cow (Cw) genomes.

From: Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps

Distance threshold, G

4

5

6

8

20

No. of markers used

248

262

276

286

298

% of markers used

80

84

89

92

96

No. of clusters

81

74

70

60

44

d(H, Ct, Cw)

129

126

119

98

63

d(A, H*) + d(H*, H)

4 + 10 = 14

3 + 11 = 14

4 + 12 = 16

1 + 12 = 13

2 + 6 = 8

d(A, Ct*) + d(Ct*, Ct)

8 + 14 = 22

8 + 17 = 25

6 + 15 = 21

9 + 11 = 20

3 +7 = 10

d(A, Cw*) + d(Cw*,Cw)

12 + 22 = 34

11 + 18 = 29

10 + 17 = 27

7 + 13 = 20

5 + 11 = 16

Tree score

70

68

64

53

34

  1. The common ancestor of all three genomes is denoted A, while preancestors for human, cat and cow genomes are denoted H*, Ct* and Cw*, respectively. The total distance between the three genomes, d(H, Ct, Cw), is defined as d(H, Ct) + d(Ct, Cw) + d(Cw, H). The tree score is defined as d(A, H) + d(A, Ct) + d(A, Cw)