Gene locus | Clinical trial/population | Medication | Statistically significant gene-therapy interaction with biochemical (B) or clinical (C) outcomes | Reference |
---|---|---|---|---|
ABCA1 | LCAS | FLUVA | Y (B) | [66] |
ACE | LCAS | FLUVA | Y (C) | [75] |
 | CARE | PRAVA | N | [76] |
 | Canada | GEMF | Y (B) | [77] |
APOA4 | PLAC1 | PRAVA | N | [35] |
APOB | Finland | LOVA | N | [31] |
 | Brazil | FLUVA | Y (B) | [67] |
APOE | Japan | HRT | Y (B) | [45] |
 | KORFPS | HRT | Y (B) | [46] |
 | Japan | HRT | Y (B) | [47] |
 | NMAPS | HRT | N | [48] |
 | Canada | PROB | Y (B) | [28] |
 | Netherlands (FH) | SIMVA | N | [29] |
 | USA (FH) | LOVA | N | [30] |
 | Finland | LOVA | N | [31] |
 | Sweden (FH) | CHOLY/PRAVA | N | [32] |
 | Japan | PRAVA | Y (B) | [33] |
 | Canada | LOVA | Y (B) | [34] |
 | PLAC1 | PRAVA | Y (B) | [35] |
 | USA | ATORVA | Y (B) | [36] |
 | Japan | BEZA | Y (B) | [37] |
 | 4S | SIMVA | Y (C) | [38] |
 | LCAS | FLUVA | Y (B) | [39] |
 | Japan | PRAVA | Y (B) | [40] |
 | Spain | ATORVA+BEZA | Y (B) | [41] |
 | Canada | FENO | Y (B) | [42] |
 | Spain | PRAVA | N | [43] |
AT2R1 | REGRESS | PRAVA | N | [101] |
B1AR | WOSCOPS | PRAVA | N | [78] |
CD14 | LCAS | FLUVA | N | [79] |
CETP | REGRESS | PRAVA | Y (C) | [21] |
 | WOSCOPS | PRAVA | Y (C) | [23] |
 | Japan | Statin | Y (B) | [24] |
 | Korea | HRT | N | [102] |
 | DALI | ATORVA | Y (B) | [25] |
CYP2D6 | Netherlands | SIMVA | Y (B) | [80] |
 | Germany | SIMVA | N | [81] |
ESR1 | ERA | HRT | Y (B) | [68] |
Factor XII | WOSCOPS | PRAVA | Y (C) | [82] |
FGA | REGRESS | PRAVA | Y (C) | [83] |
LIPC | FATS | LOVA/COLEP/NIA | Y (C) | [65] |
 | Japan | HRT | N | [103] |
IL-6 | LCAS | FLUVA | N | [79] |
 | WOSCOPS | PRAVA | Y (C) | [84] |
LDLR | South Africa (FH) | SIMVA | Y (B) | [50] |
 | Norway (FH) | LOVA | N | [51] |
 | FHRT (UK) | SIMVA (+) | N | [52] |
 | Japan (FH) | PRAVA+CHOLY | Y (B) | [53] |
 | Canada (FH) | SIMVA | Y (B) | [54] |
 | Netherlands (FH) | SIMVA | N | [55] |
 | UK (FH) | SIMVA | Y (B) | [56] |
 | Brazil (FH) | FLUVA | Y (B) | [57] |
 | Spain (FH) | SIMVA | Y (B) | [58] |
 | FH | SIMVA | Y (B) | [59] |
 | Denmark (FH) | FLUVA | N | [60] |
LPL | REGRESS | PRAVA | N | [69] |
 | LCAS | FLUVA | Y* (B) | [70] |
 | Canada | FENO | Y (B) | [42] |
MMP3 | REGRESS | PRAVA | Y (C) | [85] |
PON1 | Spain (FH) | SIMVA | N | [72] |
 | LCAS | FLUVA | N | [73] |
PPARA | Canada | GEMF | Y (B) | [71] |
 | Canada | FENO | Y (B) | [42] |
PPARG | Canada | Feno | N | [42] |
TNFA | LCAS | FLUVA | N | [79] |