Figure 1

Use of the four gene-prediction algorithms to characterise the acy-4 gene in both worm genomes. Of the 12 possible combinations of predictions, the Genefinder-Genefinder prediction pair was chosen as the best model, because this pair showed the greatest similarity to each other, excluding terminal exons. Coding sequence conservation between the two has provided evidence for as many as 12 additional N-terminal exons in the Genefinder Caenorhabditis elegans acy-4 prediction, compared with that of T01C2.1, the Worm-Base WS77 C. elegans acy-4 prediction. Four of the additional N-terminal exons (those marked with asterisks) that were predicted by FGENESH and Genefinder have subsequently been confirmed by new EST data (modified from Ref. [19])