Table 2 Expression profiling of ischaemic myocardium in animal models.
Target tissue | Experimental treatment | Number of genes affected |
|---|---|---|
Rabbit heart [29] | Two five-minute episodes of ischaemia followed by five hours of reperfusion | Strong upregulation of MAPKAPK-3 |
20-minute episode of ischaemia followed by four hours of reperfusion | Significant upregulation of HSP-27 and 70 | |
Rat in vivo myocardial infarction model [32] | Permanent coronary occlusion | 731 differentially expressed genes |
Rats' hearts [33] | Administration of angiotensin-converting enzyme (ACE) inhibitor | 37 genes clustered into 11 functional groups, ACE inhibition after myocardial infarction inhibits cardiac hypertrophy |
Rats' heart [34] | Ligation of the left anterior descending coronary artery | Expression of genes associated with a foetal transcription programme |