Figure 6

The sequence of the gene vegf , together with the single-nucleotide polymorphism (SNP) locations and their frequencies (grey vertical bars), taken from the website of the Seattle SNP project http://pga.gs.washington.edu, and the assignment of the exons to the inferred protein folds. The positions of exons along the gene are indicated in dark grey. The shaded region denotes the position of the inferred hotspot (in both populations). Exons 1 to 4 lie 5' of the hotspot, while exons 5 and 6 are on the 3' side. Below the sequence are the assignments of exonic DNA to the inferred protein folds. Exons 1 to 3 belong to the first fold (1FLTv), while DNA in exons 5 and 6 code for protein parts assigned to the second fold (1VGH). We note that in the case of vegf, no nonsynonymous polymorphism was detected in any of the exons.