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Figure 1 | Human Genomics

Figure 1

From: Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

Figure 1

Genotyping single nucleotide polymorphisms (SNPs) using high-density oligonucleotide arrays. Each SNP is queried by 80 25-mer oligonucleotides synthesised on a glass substrate. The ten oligonucleotides shown are perfect-match probes for the reference (R) and alternate (A) alleles at five offsets on the forward strand sequence relative to the SNP (-2, -1, 0, + 1, + 2). Not shown are additional mismatch probes where the middle positions of the probes shown are replaced by the three alternate nucleotides, and an equivalent set of probes for the reverse strand.

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Human Genomics

ISSN: 1479-7364