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Table 5 Genotyping results for 14 CETP gene SNPs in the test and replicate samples.

From: Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

Positiona

dbSNP

Study samples

Replicate samples

Overall pvalueb

  

Δp

pvalue

Odds ratioc

Δp

pvalue

Odds ratio

 

56729658

rs4783962

0.060

1.2 × 10-2

1.38

0.100

2.8 × 10-2

1.87

1. 4 × 10-3

56729856

rs1800775

0.193

1.1 × 10-11

2.26

0.104

1.5 × 10-1

1.40

1. 8 × 10-11

56730831

rs711752

0.165

2.4 × 10 -8

1.88

0.208

5.0 × 10 -4

2.21

5.9 × 10 -11

56730908

rs708272

0.151

7.2 × 10 -9

1.92

0.202

3.2 × 10 -4

2.25

1.2 × 10 -11

56733948

rs11508026

0.167

9.0 × 10 -8

1.85

0.186

1.9 × 10 -3

2.06

7.1 × 10 -10

56739509

rs7205804

0.146

9.7 × 10 -8

1.82

0.142

5.6 × 10 -3

1.89

1.9 × 10 -9

56740998

rs11076175

-0.101

1.2 × 10-7

0.45

-0.006

8.9 × 10-1

0.96

1.6 × 10-6

56743996

rs289716

-0.060

1.6 × 10-2

0.75

-0.039

3.9 × 10-1

0.81

1.1 × 10-2

56745805

rs4784744

-0.075

5.0 × 10-3

0.72

-0.157

8.7 × 10-3

0.53

2.4 × 10-4

56750165

rs1800774

0.009

7.5 × 10-1

1.04

0.102

5.8 × 10-2

1.53

2.5 × 10-1

56750712

rs5882

-0.073

4.4 × 10-3

0.72

-0.017

8.0 × 10-1

0.94

7.7 × 10-3

56751939

rs1800777

-0.041

1.1 × 10-3

0.33

-0.009

2.9 × 10-1

1.06

4.2 × 10-3

56752282

rs1801706

0.029

2.0 × 10-1

1.20

-0.022

2.9 × 10-1

0.73

5.0 × 10-1

56752382

rs289742

-0.023

1.2 × 10-1

0.76

-0.053

4.6 × 10-2

0.40

3.0 × 10-1

  1. a Position on GenBank sequence NC_000016.4.
  2. b Calculated from a χ2 test for the combined study and replicate samples.
  3. c Calculated as (refL /altL)/(refH /altH), where these are allele counts as in Table 4.
  4. SNPs in bold are those with significant association with HDL cholesterol in both the study and replicate populations.
  5. CETP, cholesteryl ester transfer protein dbSNP, single nucleotide polymorphism database; HDL, high-density lipoprotein.