Figure 4
From: Sibship T2association tests of complex diseases for tightly linked markers
Power curves of T H and T G at a significance level α = 0.05 using a quadric-allelic marker H 1 , when P ( H 11 ) = P ( H 12 ) = 0.35, P ( H 13 ) = P ( H 14 ) = 0.15, P D = 0.15 and N = 600 sib-pairs for the second set of parameters of the four genetic models of Table 5. Delta_11 = Δ11 = P(H11D) - P(H11)PD is a measure of linkage disequilibrium (LD) between marker H1 and disease locus D. In addition, Δ12 = -Δ11, Δ13 = - Δ14 = Δ11/2. The simulated power curves of STH and STG are calculated using combinations of both sib-pairs and sibships of size 3 and sibships of size 4; the number of sib-pairs is equal to N/2 = 300; the number of sibships of size 3 is N/2 = 120; and the number of sibships of size 4 is 3N/10 = 180; in each of N/10 = 60 sibships of size 3, one is affected and the other two are normal; in the remaining N/10 = 60 sibships of size 3, two are affected and the other one is normal; in each of N/10 = 60 sibships of size 4, one is affected and the other three are normal; in each of N/10 = 60 sibships of size 4, two are affected and the other two are normal; in the remaining N/10 = 60 sibships of size 4, three are affected and the other one is normal.