Sibship T2association tests of complex diseases for tightly linked markers

Table 1 Type I error rates of N = 200 or 300 sib-pairs at a significance level α = 0.01 using one marker, H₁, or two markers, H₁ and H₂.

Model	Test	df	# type I error rates	Mean	Std Dev	Minimum	Maximum
I	T _H	1	100	0.010808	0.0014264	0.0066	0.0140
N = 200	T _G	2	100	0.011240	0.0013923	0.0082	0.0152
II	T _H	2	100	0.011286	0.0014717	0.0070	0.0146
N = 200	T _G	4	100	0.012352	0.0015899	0.0088	0.0160
III	T _H	3	100	0.011660	0.0014348	0.0078	0.0146
N = 200	T _G	9	100	0.014352	0.0018710	0.0102	0.0196
III	T _H	3	100	0.011186	0.0015669	0.0074	0.0160
N = 300	T _G	9	100	0.013076	0.0017027	0.0084	0.0176

In model I, one bi-allelic marker H₁ is used, P(H₁₁) = P(H₁₂) = 0.50. In model II, two bi-allelic markers H₁ and H₂ are used, P(H_ij) = 0.5, i, j = 1, 2, $Δ_{H_{11} H_{21}} = 0.05$ . In model III, one quadric-allelic marker H₁ is used, P(H₂₁) = P(H₂₂) = 0.35, P(H₂₃) = P(H₂₄) = 0.15. Abbreviations: df = degrees of freedom; Std Dev = standard deviation.

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