Sibship T2association tests of complex diseases for tightly linked markers

Table 2 Type I error rates of N = 200 or 300 sibships at a significance level α = 0.01 using one marker, H₁, or two markers, H₁ and H₂.

Model	Test	df	# type I error rates	Mean	Std Dev	Minimum	Maximum
I	T _H	1	100	0.010642	0.0014406	0.0062	0.0134
N = 200	T _G	2	100	0.011278	0.0015023	0.0076	0.0154
II	T _H	2	100	0.011096	0.0014418	0.0078	0.0154
N = 200	T _G	4	100	0.012138	0.0014825	0.0082	0.0154
III	T _H	3	100	0.011536	0.0014156	0.070	0.0158
N = 200	T _G	9	100	0.014202	0.0016562	0.096	0.0182
III	T _H	3	100	0.011098	0.0015214	0.0076	0.0152
N = 300	T _G	9	100	0.012790	0.0016883	0.0086	0.0186

The number of sib-pairs is equal to N/2; in each sib-pair, one sibling is affected and the other is normal. The number of sibships of size 3 is N/2; in each of N/4 sibships of size 3, one is affected and the other two are normal; in the remaining N/4 sibships of size 3, two are affected and the other one is normal. The other parameters of each model are the same as those of Table 1. Abbreviations: df = degrees of freedom; Std Dev = standard deviation.

ISSN: 1479-7364