Sibship T2association tests of complex diseases for tightly linked markers

Table 3 Type I error rates of N = 200 or 300 sibships at a significance level α = 0.01 using one marker, H₁, or two markers, H₁ and H₂.

Model	Test	df	# type I error rates	Mean	Std Dev	Minimum	Maximum
I	T _H	1	100	0.010670	0.0014040	0.0072	0.0136
N = 200	T _G	2	100	0.011156	0.0015397	0.0066	0.0142
II	T _H	2	100	0.011218	0.0014678	0.0078	0.0166
N = 200	T _G	4	100	0.012304	0.0011921	0.0092	0.0156
III	T _H	3	100	0.011518	0.0014639	0.0082	0.015
N = 200	T _G	9	100	0.014356	0.0015381	0.0102	0.018
III	T _H	3	100	0.011228	0.0013312	0.0078	0.0160
N = 300	T _G	9	100	0.012544	0.0015203	0.0086	0.0182

The number of sib-pairs is equal to N/2; the number of sibships of size 3 is N/5; and the number of sibships of size 4 is 3N/10. In each sib-pair, one sibling is affected and the other is normal. In each of N/10 sibships of size 3, one is affected and the other two are normal; in the remaining N/10 sibships of size 3, two are affected and the other is normal. In each of N/10 sibships of size 4, one is affected and the other three are normal; in each of N/10 sibships of size 4, two are affected and the other two are normal; in the remaining N/10 sibships of size 4, three are affected and the other one is normal. The other parameters of each model are the same as those of Table 1. Abbreviations: df = degrees of freedom; Std Dev = standard deviation.

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