Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

Supplementary Table 1 Sequences used in Phylogenetic Analysis by Maximum Likelihood analysis.

Gene	Domain	Species	Accession^a
CAR	Full-length	Human	NM_005122
		Rhesus	AY116212
		Mouse	NM_009803
		Rat	NM_022941
		Fur Seal	AB109554
		Baikal seal	AB109553
	LBD only	Dog	AAEX01049487 and AAEX01049488
	DBD only	Cow	30573, December 10, 2004
PXR	Full-length	Human	NM_003889
		Chimpanzee	Nov. 2003 chimpanzee Arachne assembly, NCBI Build 1 version 1, UCSC: panTro1
		Rhesus	AF454671
		Rabbit	AF188476
		Mouse	AF031814
		Rat	AF151377
	LBD only	Dog	AF454670
		Pig	AF454672
VDR	Full-length	Human	NM_000376
		Cotton-top tamarin	AF354232
		Mouse	NM_009504
		Rat	NM_017058
	DBD only	Chimpanzee	Nov. 2003 chimpanzee Arachne assembly, NCBI Build 1 version 1, UCSC: panTro1
TRα	Full-length	Human	NM_003250
		Sheep	Z68308
		Pig	AJ005797
		Rat	M18028
		Mouse	NM_178060
	DBD only	Chimpanzee	Nov. 2003 chimpanzee Arachne assembly, NCBI Build 1 version 1, UCSC: panTro1
FXR	Full-length	Human	NM_005123
		Chimp	Nov. 2003 chimpanzee Arachne assembly, NCBI Build 1 version 1, UCSC: panTro1
		Rabbit	AF497630
		Golder hamster	AF478441
		Mouse	NM_009108
		Rat	NM_021745

^a All accession number refer to Genbank sequences unless otherwise specified.
Abbreviations: CAR, constitutive androstane receptor: PXR, pregnane X receptor; VDR, vitamin D receptor; TRα, thyroid receptor-α, FXR, farnesoid X receptor; DBD, DNA binding domain; LBD, ligand binding domain; NCBI, The National Center for Biotechnology Information; UCSC, The University of California Santa Cruz.

ISSN: 1479-7364