Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

Table 1 Summary statistics of sequence variation at the CAR locus.

Sample	S^a	π^b	θ_w^c	TD^d	θ_w/div^e
African Americans	16	0.50 (13)	0.89 (33)	-1.37 (6)	11.7 (57)
Europeans	12	0.55 (41)	0.66 (9.5)	-0.48 (23)	8.7 (78)
Han	6	0.42	0.33	0.72

^a Number of segregating sites.
^b Nucleotide diversity per base pair (× 10^-3). Numbers in parentheses indicate the percentile rank of π relative to the distribution of π values in the Seattle SNP genes.
^cWatterson's estimator of the population mutation rate parameter θ (= 4Nμ) per bp (× 10^-3) [37].
^d Tajima's D (TD) [38]. Numbers in parenthesis indicate the percentile rank of the TD value relative to the distribution of TD values in the Seattle SNP genes.
^e Ratio of θ_W to the amount of sequence divergence between human and chimpanzee (per cent). Numbers in parenthesis indicate the percentile rank of the θ_W:div value relative to the distribution of θ_W:div values in the Seattle SNP genes.

ISSN: 1479-7364