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Table 4 Phylogenetic analysis by maximum likelihood (PAML) models from analysis of sequence data from the CAR, PXR, VDR, FXR and TRα genes (values in parentheses indicate percentage of codons falling in a particular ω category).

From: Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

PAML model

CAR (NR1I3)

 

Full sequence

M3, ω = 0.03 (51%), 0.47 (49%)

DBD only

M0, ω = 0.1598

LBD only

M3, ω = 0.06 (68%), 0.72 (32%)

VDR (NR1I1)

 

Full sequence

M3, ω = 0.00001 (77%), 0.333 (23%)

DBD only

M0, ω = 0.0085

LBD only

M3, ω = 0.00001 (67%), 0.32 (33%)

PXR (NR1I2)

 

Full sequence

M3, ω = 0.049 (79%), 0.666 (21%)

DBD only

M0, ω = 0.0441

LBD only

M3, ω = 0.01 (51%), 0.26 (42%), 1.23 (7%)

TRα (NR1I2)

 

Full sequence

M0, ω = 0.02

DBD only

M0, ω = 0.0001

LBD only

M0, ω = 0.01

FXR (NR1H4)

 

Full sequence

M3, ω = 0.00001 (72%), 0.22 (28%)

DBD only

M0, ω = 0.0137

LBD only

M3, ω = 0.00001 (83%), 0.295 (17%)

  1. Abbreviations: CAR, constitutive androstane receptor; PXR, pregnane X receptor;
  2. VDR, vitamin D receptor; FXR, farnesoid X receptor; TRα, thyroid receptor-α; DBD,
  3. DNA binding domain; LBD, ligand binding domain.