Table 4 Conservation of novel missense mutations in α-Gal A and α-Gal B orthologues.
Eukaryotic (22) | Mammalian (4) | α-Gal B orthologues (8) | Conservation score* | |
|---|---|---|---|---|
N34K | 13 | 3 | 7 | ++ |
T41I | 1 | 3 | 0 | - |
D93V | 18 | 3 | 8 | +++ |
R112S | 5 | 3 | 7 | + |
L166G | 4 | 3 | 0 | - |
G171D | 7 | 3 | 8 | + |
M187T | 16 | 4 | 5 | ++ |
S201F/Y | 15 | 4 | 8 | ++ |
D234E | 13 | 3 | 6 | ++ |
W236R | 13 | 3 | 7 | ++ |
D264Y | 20 | 3 | 8 | +++ |
M267R | 14 | 3 | 7 | ++ |
V269M | 3 | 3 | 1 | - |
G271V/S | 21 | 3 | 7 | +++ |
S276G | 11 | 3 | 7 | ++ |
Q283P | 7 | 3 | 7 | + |
A285P/D | 9 | 3 | 7 | + |
M290I | 10 | 3 | 1 | + |
P293T | 17 | 3 | 8 | +++ |
Q312H | 5 | 3 | 6 | + |
Q321R | 20 | 3 | 8 | +++ |
G328V | 9 | 3 | 7 | + |
E338K | 14 | 3 | 6 | ++ |
A348P | 1 | 3 | 6 | + |
E358A | 3 | 3 | 1 | - |
Q386P | 3 | 3 | 6 | + |