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Table 2 Comparison of different error rates and analysis methods.

From: Detecting multiple associations in genome-wide studies

 

Error control for

Appropriate for

 

Whole study

Single test

Association study

Expression study

Family wise error, strong

Yes (1)

Yes (1)

No

No

Family wise error, weak

Yes(1)

No

Yes

Yes

Minimum p-value

Yes (1)

Yes (1)

Some what

No

Truncated p-value product

Yes (1)

No

Yes

Possibly

Random gene effects model

Yes (1)

Yes (2)

Possibly

Yes

False discovery rate

Yes (3)

No

No

Yes

Q-value

Yes (3)

Some (3)

No

Yes

Local false discovery rate

Yes (2)

Yes (2)

Yes

Yes

False-positive report probability

Yes (3)

Some (3)

Yes

Yes

  1. 'Error control' indicates whether a method provides some measure of error: (1) type-I error; (2) posterior probability of association; (3) expected proportion of false discoveries in a series of tests. 'Appropriate for' indicates whether, in the view of the authors, a method is suitable for genome-wide association or expression studies, based on the factors in Table 1.