Testing groups of genomic locations for enrichment in disease loci using linkage scan data: A method for hypothesis testing

Table 1 The power of our method for different simulated models (five, ten or 20 disease loci, 1,180 or 590 sibling pairs, relative risk (RR) of 2 or 3) different levels of enrichment for true loci and different levels of significance.

# Real loci	Group composition		Power: 1,180 sibling pairs, RR = 3%		Power:1,180 sibling pairs, RR = 2%		Power: 590 sibling pairs, RR = 3%		Power: 590 sibling pairs, RR = 2%
	Real loci	False	α = 0.05	α = 0.01	α = 0.05	α = 0.01	α = 0.05	α = 0.01	α = 0.05	α = 0.01
	5	0	100	100	100	92	100	96	100	84
	5	3	100	98	90	71	94	88	80	51
	5	5	99	94	81	58	93	79	70	40
5	5	10	95	76	69	42	84	58	53	25
	3	0	100	95	88	72	97	88	82	52
	3	2	94	78	71	43	84	61	57	30
	3	5	80	52	54	27	67	37	38	16
	10	0	100	100	100	92	100	92	72	48
	10	5	99	92	89	63	88	64	54	29
	10	10	94	77	78	48	75	48	46	22
	10	20	80	54	58	30	60	30	35	14
10	5	0	90	72	75	48	77	44	48	20
	5	3	75	49	56	28	53	26	32	13
	5	5	68	42	49	24	47	21	29	11
	5	10	53	28	35	15	35	16	22	7
	20	0	100	76	68	44	65	35	32	12
	20	10	80	49	56	31	47	23	26	10
	20	20	67	37	47	21	40	18	24	10
	20	40	49	24	36	16	31	14	17	6
	15	0	84	58	61	35	53	26	29	13
20	15	10	64	34	45	20	40	16	23	9
	15	20	51	23	36	15	29	13	18	7
	15	30	41	19	29	12	26	9	14	5
	10	0	67	40	47	23	41	18	25	9
	10	5	51	24	38	15	32	13	19	6
	10	10	41	19	31	11	26	9	16	6
	10	15	35	14	24	9	23	8	15	5

ISSN: 1479-7364