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Table 2 Results of simulated scans with 1,180 sibling pairs regarding their success in identifying the disease gene locations.

From: Testing groups of genomic locations for enrichment in disease loci using linkage scan data: A method for hypothesis testing

   Number of top findings
Simulated model # Disease loci 1
Real loci(%)
Average NPL
3
Real loci(%)
Average NPL
5
Real loci(%)
Average NPL
10
Real loci(%)
Average NPL
20
Real loci (%)
Average NPL
H = 0.7, K ≈ 0.03, RR = 3 5 0.92 (92%)
4.22
2.28 (76%)
3.70
3.16 (63%)
3.36
4.04 (40%)
2.86
4.4 (22%)
2.29
  10 0.72 (72%)
3.55
2.12 (71%)
3.22
3.24 (65%)
2.98
4.8 (48%)
2.58
6.32 (32%)
2.12
  20 0.52 (52%)
3.15
1.48 (49%)
2.87
2.24 (45%)
2.71
4.24 (42%)
2.41
8.04 (40%)
2.03
H = 0.7, K ≈ 0.03, RR = 2 5 0.75 (75%)
3.24
1.54 (51%)
2.91
1.96 (39%)
2.68
2.79 (28%)
2.34
3.58 (18%)
1.93
  10 0.56 (56%)
3.10
1.44 (48%)
2.83
2.16 (43%)
2.62
3.32 (33%)
2.30
5.08 (25%)
1.91
  20 0.4 (40%)
2.79
1 (33%)
2.54
1.64 (33%)
2.39
3.24 (32%)
2.12
5.56 (28%)
1.76
  1. Simulation parameters: H = heritability, K = prevalence, RR = relative risk for each risk allele. The number of simulated disease loci is shown. For the one, three, five, ten and 20 top scoring loci for each of the 25 simulated genome scans, we show how many coincided with true disease loci (and their percentages), as well as their average non-parametric linkage (NPL) score.