Genome-wide approaches to understanding human ageing

Table 1 Selected genes for which polymorphisms have been reported to correlate with human longevity.

Gene	Gene function	Reference
3' APOB-VNTR	Apolipoprotein B	[30]
5HTT	Serotonin transporter	[31]
ACE	Angiotensin-converting enzyme	[32]
APOE	Apolipoprotein E	[32]
CETP	Cholesteryl ester transfer protein	[33, 34]
GH1	Growth hormone	[35]
IGF-1R	Insulin-likegrowth factor (IGF)-I receptor	[36]
IL-10	Interleukin 10	[37]
KLOTHO	Insulin/IGF-I-repressing hormone	[38–40]
MTND2	Mitochondrial NADH dehydrogenase	[41]
MTP	Microsomal triglyceride transfer protein	[20]
NR3C1	Glucocorticoid receptor	[42]
PI3KCB	Phosphatidylinositol 3-kinase catalytic subunit	[36]
PPARG	Peroxisome proliferator-activated receptor gamma 2	[43]
SHC1	SHC-transforming protein 1	[44]
SIRT3	Sirtuin protein deacetylase	[45]
TH	Tyrosine hydroxylase	[46]
TLR4	Toll-likereceptor 4	[47]
TP53	Tumour suppressor p53	[48, 49]

Obvious life span-shortening disease alleles have been excluded. It should be noted that, in many cases, the reported correlation with longevity has been disputed by subsequent work.
Abbreviations: NADH = the reduced form of nicotinamide adenine dinucleotide;
SHC = Src homology 2 domain-containing.

ISSN: 1479-7364