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Table 1 Selected genes for which polymorphisms have been reported to correlate with human longevity.

From: Genome-wide approaches to understanding human ageing

Gene Gene function Reference
3' APOB-VNTR Apolipoprotein B [30]
5HTT Serotonin transporter [31]
ACE Angiotensin-converting enzyme [32]
APOE Apolipoprotein E [32]
CETP Cholesteryl ester transfer protein [33, 34]
GH1 Growth hormone [35]
IGF-1R Insulin-likegrowth factor (IGF)-I receptor [36]
IL-10 Interleukin 10 [37]
KLOTHO Insulin/IGF-I-repressing hormone [3840]
MTND2 Mitochondrial NADH dehydrogenase [41]
MTP Microsomal triglyceride transfer protein [20]
NR3C1 Glucocorticoid receptor [42]
PI3KCB Phosphatidylinositol 3-kinase catalytic subunit [36]
PPARG Peroxisome proliferator-activated receptor gamma 2 [43]
SHC1 SHC-transforming protein 1 [44]
SIRT3 Sirtuin protein deacetylase [45]
TH Tyrosine hydroxylase [46]
TLR4 Toll-likereceptor 4 [47]
TP53 Tumour suppressor p53 [48, 49]
  1. Obvious life span-shortening disease alleles have been excluded. It should be noted that, in many cases, the reported correlation with longevity has been disputed by subsequent work.
  2. Abbreviations: NADH = the reduced form of nicotinamide adenine dinucleotide;
  3. SHC = Src homology 2 domain-containing.