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Table 2 Potential conserved determinants of longevity.

From: Genome-wide approaches to understanding human ageing

Gene family Description
Catalase Increased catalase activity increases life
span in yeast [62] and mice [63]
Insulin/insulin-like
growth factor-I receptor
Mutation of insulin and insulin-likegrowth
factor-I receptor genes increases life span
in worms, [64, 65] flies [66] and mice [67, 68]
Rpd3 Deletion of RPD3 increases life span in
yeast [69] and flies [70]
Sch9/Akt Decreased SCH9/AKT activity increases
life span in yeast [25, 26, 62, 71] and worms [7274]
Sir2 Increased expression of Sir2-family
proteins increases life span in yeast, [75]
worms [76] and flies [77]. Avariant allele of a
human homolog, SIRT3, isreported to
correlated with longevity [78, 45]
Superoxide
dismutase
Increased superoxide dismutase activity
increases life span in yeast [62] and flies [79]
TOR Decreased TOR activity increases life span
in yeast, [26, 80] worms [81, 82] and flies [83]
  1. Genes shown have been reported to increase life span when mutated in more than one organism.