The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population

Table 2 Association analysis of eight cystolic aldehyde dehydrogenase (ALDH1A1) polymorphisms with AUDIT score

Variant	Chromosomal location (bp)^a	Gene location	Alleles^b		MAF^c	Allelic AUDIT score means^d		Genotypic AUDIT score means^e			Genotypic association (pvalue)		Mode of inheritance
			Allele 1	Allele 2		Allele 1	Allele 2	1/1	1/2	2/2	General^f	Best model^g
rs348479	74702120	3' UTR	G	T	0.177	17.79	19.66	11.00	19.47	19.33	0.08	0.025	Dominant
rs348472	74710880	Intron 1 1	A	G	0.035	20.67	19.30	28.00	18.90	19.08	0.75	0.44	Dominant
rs610529	74723144	Intron 8	A	G	0.399	20.21	17.85	20.50	19.07	14.65	0.027	0.013	Recessive
rs2288087	74733858	Intron 4	A	T	0.475	18.94	19.71	17.53	19.61	19.34	0.48	0.23	Dominant
rs13959	74735702	Exon 3	A	G	0.472	19.65	19.00	19.34	19.48	17.83	0.62	0.33	Recessive
rs348449	74744802	Intron 2	A	G	0.033	19.18	24.20	18.78	24.44	22.00	0.13	0.043	Dominant
rs595958	74750694	Intron 1	C	T	0.354	19.52	19.01	19.19	19.70	17.44	0.53	0.28	Recessive
rs918836	74777539	5' UTR	C	G	0.278	19.03	19.48	18.87	18.79	19.38	0.91	0.66	Recessive

Abbreviations: AUDIT, Alcohol Use Disorder Identification Test; MAF, minor allele frequency.
^abp = base-pair position on NCBI dbSNP Build 128.
^bThe allele with the lowest frequency is italicised.
^cMinor allele frequency of the italicised allele in the volunteers from the general population (n = 201).
^dAllelic AUDIT score means were calculated in Qtphase¹⁷.
^eGenotypic AUDIT score means were calculated in SAS (SAS Institute, version 8.0, Cary, NC) using a general test of association.
^fProbability for general association between each SNP and the AUDIT score using analysis of variance models.
^gLowest probability of association assuming a genetic mode of inheritance (given in Table) with respect to allele 2.

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