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Table 2 Association analysis of eight cystolic aldehyde dehydrogenase (ALDH1A1) polymorphisms with AUDIT score

From: The role of aldehyde dehydrogenase-1 (ALDH1A1) polymorphisms in harmful alcohol consumption in a Finnish population

Variant Chromosomal location (bp)a Gene location Allelesb MAFc Allelic AUDIT score meansd Genotypic AUDIT score meanse Genotypic association (pvalue) Mode of inheritance
    Allele 1 Allele 2   Allele 1 Allele 2 1/1 1/2 2/2 Generalf Best modelg  
rs348479 74702120 3' UTR G T 0.177 17.79 19.66 11.00 19.47 19.33 0.08 0.025 Dominant
rs348472 74710880 Intron 1 1 A G 0.035 20.67 19.30 28.00 18.90 19.08 0.75 0.44 Dominant
rs610529 74723144 Intron 8 A G 0.399 20.21 17.85 20.50 19.07 14.65 0.027 0.013 Recessive
rs2288087 74733858 Intron 4 A T 0.475 18.94 19.71 17.53 19.61 19.34 0.48 0.23 Dominant
rs13959 74735702 Exon 3 A G 0.472 19.65 19.00 19.34 19.48 17.83 0.62 0.33 Recessive
rs348449 74744802 Intron 2 A G 0.033 19.18 24.20 18.78 24.44 22.00 0.13 0.043 Dominant
rs595958 74750694 Intron 1 C T 0.354 19.52 19.01 19.19 19.70 17.44 0.53 0.28 Recessive
rs918836 74777539 5' UTR C G 0.278 19.03 19.48 18.87 18.79 19.38 0.91 0.66 Recessive
  1. Abbreviations: AUDIT, Alcohol Use Disorder Identification Test; MAF, minor allele frequency.
  2. abp = base-pair position on NCBI dbSNP Build 128.
  3. bThe allele with the lowest frequency is italicised.
  4. cMinor allele frequency of the italicised allele in the volunteers from the general population (n = 201).
  5. dAllelic AUDIT score means were calculated in Qtphase17.
  6. eGenotypic AUDIT score means were calculated in SAS (SAS Institute, version 8.0, Cary, NC) using a general test of association.
  7. fProbability for general association between each SNP and the AUDIT score using analysis of variance models.
  8. gLowest probability of association assuming a genetic mode of inheritance (given in Table) with respect to allele 2.