Supplementary Table 1 Supplementary Table 1a. A majority of perifosine-specific gene expression levels are associated with the cytotoxicity of edelfosine
From: Genome-wide identification of genetic determinants for the cytotoxicity of perifosine
Symbol | Perifosine (p-value) | Edelfosine (p-value) | Perifosine (r-value) | Edelfosine (r-value) | Notes |
|---|---|---|---|---|---|
NS-cDNA | Â | Â | Â | Â | Â |
ATF2 | 0.0000 | 0.0075 | -0.560 | -0.348 | Significant |
TRA2A | 0.0008 | 0.0005 | -0.438 | -0.456 | Significant |
ETS2 | 0.0005 | 0.0004 | -0.438 | -0.449 | Significant |
UBE2D3 | 0.0009 | 0.0026 | -0.419 | -0.382 | Significant |
VEGFB | 0.0006 | 0.0001 | 0.443 | 0.502 | Significant |
ANP32A | 0.0002 | 0.0003 | 0.492 | 0.469 | Significant |
GL-U95 | Â | Â | Â | Â | Â |
REG4 | 0.0000 | 0.0004 | -0.579 | -0.443 | Significant |
SLCO4A1 | 0.0000 | 0.0060 | -0.518 | -0.351 | Significant |
RPL18A | 0.0000 | 0.0093 | -0.500 | -0.333 | Significant |
OAZ2 | 0.0000 | 0.0018 | 0.527 | 0.394 | Significant |
DZIP3 | 0.0000 | 0.0001 | 0.580 | 0.478 | Significant |
NP-U95 | Â | Â | Â | Â | Â |
STK39 | 0.0001 | 0.0004 | -0.479 | -0.449 | Significant |
FAM32A | 0.0002 | 0.0529 | -0.460 | -0.253 | Marginal |
MAPKAPK3 | 0.0003 | 0.0920 | -0.454 | -0.221 | Marginal |
RAB8A | 0.0005 | 0.0018 | -0.441 | -0.399 | Significant |
STK17B | 0.0006 | 0.0243 | -0.435 | -0.293 | Significant |
TCF3 | 0.0006 | 0.0054 | -0.435 | -0.358 | Significant |
PARP4 | 0.0006 | 0.0000 | -0.433 | -0.519 | Significant |
PSMA2 | 0.0006 | 0.0060 | -0.432 | -0.354 | Significant |
DGKE | 0.0007 | 0.0019 | -0.429 | -0.396 | Significant |
PVT1 | 0.0010 | 0.0018 | 0.418 | 0.398 | Significant |
ELOVL2 | 0.0009 | 0.0005 | 0.419 | 0.438 | Significant |
SMARCA3 | 0.0009 | 0.0038 | 0.420 | 0.371 | Significant |
USP6 | 0.0007 | 0.0094 | 0.428 | 0.335 | Significant |
NFATC4 | 0.0005 | 0.0305 | 0.437 | 0.282 | Significant |
IGF1R | 0.0005 | 0.0570 | 0.437 | 0.249 | Marginal |
POU4F1 | 0.0005 | 0.0023 | 0.439 | 0.390 | Significant |
PDLIM3 | 0.0005 | 0.0058 | 0.440 | 0.355 | Significant |
CBS | 0.0004 | 0.0094 | 0.443 | 0.336 | Significant |
ARMCX2 | 0.0004 | 0.0008 | 0.447 | 0.425 | Significant |
OPHN1 | 0.0003 | 0.0194 | 0.459 | 0.304 | Significant |
ZNF609 | 0.0002 | 0.0091 | 0.462 | 0.337 | Significant |
ATN1 | 0.0001 | 0.0754 | 0.474 | 0.233 | Marginal |
DZIP3 | 0.0001 | 0.0093 | 0.479 | 0.336 | Significant |
PPBPL2 | 0.0001 | 0.0081 | 0.487 | 0.342 | Significant |
MPDZ | 0.0000 | 0.0001 | 0.534 | 0.498 | Significant |
SKIV2L | 0.0000 | 0.0007 | 0.557 | 0.427 | Significant |
GABRG3 | 0.0000 | 0.0000 | 0.601 | 0.533 | Significant |
Supplementary Table 1b. The perifosine-specific SNPs are associated with the cytotoxicity of edelfosine | |||||
dbSNP | Perifosine ( p -value) | Perifosine ( r -value) | Edelfosine ( p -value) | Edelfosine ( r -value) | Notes |
rs4236669 | 2.80E-07 | 0.64 | I.75E-03 | 0.42 | Significant |
rsI468400 | 8.80E-07 | 0.62 | 6.27E-04 | 0.46 | Significant |
rsI345938 | 2.60E-06 | 0.58 | 3.66E-05 | 0.52 | Significant |