Pharmacokinetic parameter | Group 1 (*1A/*1A) n= 6 | Group 2 (*1A/*1B or *1B/*1B) n= 7 | Group 3 (*5, *15, *16, or *17 haplotype carriers) n= 13 | pvalue |
---|---|---|---|---|
AUC0-∞ (ng*h/ml) | 1601 ± 451 (1128, 2074) | 2019 ± 624 (1442, 2595) | 1699 ± 417 (1447, 1951) | 0.26 |
CL/F (ml/h) | 2673 ± 766 (1869, 3477) | 2153 ± 673 (1530, 2775) | 2495 ± 633 (2112, 2877) | 0.37 |
CL/F/kg (ml/h/kg) | 40.9 ± 9.4 (31, 50.8) | 33 ± 9.2 (24.5, 41.5) | 37.5 ± 10 (31.5, 43.6) | 0.35 |
t1/2 (h) | 4.1 ± 0.9 (3.2, 5) | 3.9 ± 0.8 (3.2, 4.7) | 3.8 ± 0.8 (3.3, 4.3) | 0.78 |
Cmax (ng/ml) | 337 ± 125 (206, 469) | 409 ± 86 (329, 489) | 383 ± 113 (315, 451) | 0.50 |
Tmax (hr) | 1.0 ± 0.6 (0.4, 1.6) | 0.8 ± 0.4 (0.4, 1.2) | 0.9 ± 0.5 (0.7, 1.2) | 0.68 |