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Table 2 Venous blood acetaldehyde concentrations in male adults with different ADH and ALDH genotypes after alcohol ingestion

From: Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2on blood acetaldehyde concentrations

Ethanol

dose (g/kg)

Combinatorial genotype

Subject

number

Mean peak

acetaldehyde

 
 

ALDH2

ADH1B

(n)

(μM)

Author

0.2

*1/*1

*2/*2

6

1.0

Peng et al.[29]

0.2

*1/*2

*2/*2

6

24

Peng et al.[29]

0.2

*2/*2

*2/*2

6

75

Peng et al.[29]

0.3

*1/*1

*1/*1

6

0.3

Peng et al.[30]

0.3

*1/*1

*2/*2

6

0.2

Peng et al.[30]

0.3

*1/*2

*1/*1

6

60

Peng et al.[30]

0.3

*1/*2

*2/*2

6

60

Peng et al.[30]

0.4

*1/*1

*1/*1

5

3.3

Mizoi et al.[36]

0.4

*1/*1

*1/*2

8

4.8

Mizoi et al.[36]

0.4

*1/*1

*2/*2

20

4.2

Mizoi et al.[36]

0.4

*1/*2

*1/*1

4

23

Mizoi et al.[36]

0.4

*1/*2

*1/*2

9

23

Mizoi et al.[36]

0.4

*1/*2

*2/*2

16

24

Mizoi et al.[36]

0.4

*2/*2

*2/*2

6

79

Mizoi et al.[36]

0.5

*1/*1

*1/*1

8

3.3

Peng et al.[31]

0.5

*1/*1

*2/*2

8

4.0

Peng et al.[31]

0.5

*1/*2

*2/*2

16

76

Peng et al.[31]

0.5

*2/*2

*2/*2

1a

125

Chen et al.[21]

  1. aAn alcohol-dependent patient with normal liver function.
  2. Abbreviations: ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase