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Table 1 Biological processes and molecular function enrichment in HH genes closer than 500 base pairs

From: Orientation, distance, regulation and function of neighbouring genes

Biological process

Observed

Expected

pValue

DNA metabolism

39

13.14

6.0 × 10-7

Nucleoside, nucleotide and nucleic acid metabolism

181

121.99

1.2 × 10-6

DNA repair

24

6.17

6.9 × 10-6

rRNA metabolism

12

2.41

1.2 × 10-3

Other intracellular protein traffic

11

2.26

3.6 × 10-3

Protein biosynthesis

40

21.57

2.9 × 10-2

Chromatin packaging and remodelling

21

8.65

3.5 × 10-2

Protein complex assembly

10

2.48

3.7 × 10-2

Molecular function

Observed

Expected

p Value

Nucleic acid binding

170

104.0

3.51 × 10-9

Histone

12

3.14

1.67 × 10-2

Dehydrogenase

21

8.21

1.97 × 10-2

Oxidoreductase

38

22

3.06 × 10-2

  1. Biological processes and molecular functions enriched in the genes that are HH orientated and closer than 1 kb from each other. The number of genes observed, with annotation for each process, out of the total of 942 genes in the group is shown, as well as the expected number based on the frequencies of annotations for all RefSeq genes. All values are calculated using the PANTHER bioinformatics engine and p values are Bonferroni corrected.
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Human Genomics

ISSN: 1479-7364