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Table 1 Human SLC gene superfamily, including description of the gene products

From: Analysis and update of the human solute carrier (SLC) gene superfamily

Protein

family

Description

Number of

members

Pfam

Domain

GenBank

accession

number

SLC1

High-affinity glutamate and neutral amino acid transporter family

7

PF00375

SDF

NP_004161

SLC2

Facilitative glucose transporter (GLUT) family

14; 5 pseudo

PF00083

Sugar_tr

NP_006507

SLC3

Heavy subunits of the heteromeric amino acid transporters

2

PF00128

Alpha-amylase

NP_000332

SLC4

Bicarbonate transporter family

10

PF07565

Band_3_cyto

NP_000333

   

PF00955

HC03_cotransp

 

SLC5

Na+/glucose co-transporter family

12

PF00474

SSF

NP_000334

SLC6

Na+- and Cl--dependent neurotransmitter symporter family

19; 3 pseudo

PF00209

SNF

NP_003033

SLC7

Cationic amino acid transporter/glycoprotein- associated amino acid transporter family

14; 1 pseudo

PF00324

AA_permease

NP_003036

SLC8

Na+/Ca2+ exchanger family

3

PF03160

Na_Ca_ex

NP_066920

   

PF01699

Calx_eta

 

SLC9

Na+/H+ exchanger family

11; 4 pseudo

PF00999

Na_H_Exchanger

 

SLC10

Na+/bile salt co-transporter family

7

PF01758

SBF

NP_003040

SLC11

Proton-coupled metal ion transporter family

2

PF01566

Nramp

NP_000569

SLC12

Electroneutral cation/Cl- co-transporter family

9

PF00324

AA_permease

NP_000329

   

PF08403

  

SLC13

Na+/SO42-/carboxylate co-transporter family

5

PF00939

Na_sulph_symp

NP_071889

SLC14

Urea transporter family

2

PF03253

UT

NP_056949

SLC15

Proton oligopeptide co-transporter family

4

PF00854

PTR2

NP_005064

SLC16

Monocarboxylate transporter family

14

PF07690

MFS_1

NP_003042

SLC17

Vesicular glutamate transporter family

8

PF07690

MFS_1

NP_005065

SLC18

Vesicular amine transporter family

3

PF07690

MFS_1

NP_003044

SLC19

Folate/thiamine transporter family

3

PF01770

Folate_carrier

NP_919231

SLC20

Type-III Na+/H2PO4- co-transporter family

2; 1 pseudo

PF01384

PH04

NP_006740

SLC22

Organic cation/anion/zwitterion transporter family

23

PF07690

MFS_1

NP_003048

SLC23

Na+-dependent ascorbic acid transporter family

4

PF00860

Xan_ur_permease

NP_005838

SLC24

Na+/Ca2+ and Na+/K+ exchanger family

6

PF01699

Na_Ca_ex

NP_004718

SLC25

Mitochondrial carrier family

43; 4 pseudo

PF00153

Mito_carr

NP_005975

SLC26

Multifunctional anion exchanger family

11

PF01740

Sulfate_transp

NP_998778

   

PF00916

STAS

 

SLC27

Fatty acid transport protein family

6

PF00501

AMP-binding

NP_940982

SLC28

Na+-coupled nucleoside transport family

3

PF07670

Gate

NP_004204

   

PF07662

Nucleos_tra2_C

 
   

PF01773

  

SLC29

Facilitative nucleoside transporter family

4

PF01733

Nucleoside_tran

NP_001071642

SLC30

Zn2+ efflux family

10

PF01545

Cation_efflux

NP_067017

SLC31

Copper transporter family

2; 1 pseudo

PF04145

Ctr

NP_001850

SLC32

Vesicular inhibitory amino acid transporter family

1

PF01490

Aa_trans

NP_542119

SLC33

Acetyl coenzyme A transporter family 22

1

IPR004752

2A0125

NP_004724

SLC34

Type-II Na+/HPO42- co-transporter family

3

PF02690

Na_Pi_cotrans

NP_003043

SLC35

(A, B, C, D, E, F)

Nucleoside-sugar transporter family

23

PF04142

Nuc_sug_transp

NP_006407

SLC36

Proton-coupled amino acid transporter family

4

PF01490

Aa_trans

NP_510968

SLC37

Sugar-PO43-/PO43- exchanger family

4

PF07690

MFS_1

NP_061837

SLC38

System A & N, Na+-coupled neutral amino acid transporter family

11

PF01490

Aa_trans

NP_109599

SLC39

Metal (M2+) ion transporter family

14

PF02535

Zip

NP_055252

SLC40

Basolateral iron transporter family

1

PF06963

FPN1

NP_055400

SLC41

MgtE-like Mg2+ transporter family

3

PF01769

MgtE

NP_776253

SLC42

Rh-associated glycoproteins; NH4+ transporter family

3

   

SLC43

Na+-independent system-L-like amino acid transporter family

3

  

NP_003618

SLC44

Choline-like transmembrane transporter activity

5

PF04515

DUF580

NP_536856

SLC45

Putative sugar/H+ symporter activity

4

PF07690

MFS_1

NP_001073866

SLC46

Folic acid transporter (heme-containing) activity

3

PF07690

MFS_1

NP_542400

SLC47

Polyspecific H+/organic cation exporter

2

PF01554

MatE

NP_060712

SLCO1

(A, B, C)

Drug, organic anion transporter family

4

PF07648

OATP

NP_602307

   

PF03137

  

SLCO2

Prostaglandin and steroid sulphate transporter family

2

PF07648

OATP

NP_005621

   

PF03137

  

SLCO3

Drug and organic anion transporter activity

1

PF07648

OATP

NP_037404

   

PF03137

KAzal_2

 

SLCO4

Thyroid hormone transmembrane transporter activity

2

PF07648

OATP

NP_057438

   

PF03137

  

SLCO5

Drug and organic anion transporter activity

1

PF07648

OATP

NP_112220

   

PF03137

  

SLCO6

Drug and organic anion transporter activity

1

PF07648

OATP

NP_775759

   

PF03137

Kazal_2

 

UCP1

Oxidative phosphorylation uncoupling activity (proton carrier)

1

PF00153

Mito_carr

NP_068605

UCP2

Oxidative phosphorylation uncoupling activity (proton carrier)

1

PF00153

Mito_carr

NP_003346

UCP3

Oxidative phosphorylation uncoupling activity (proton carrier)

1

PF00153

Mito_carr

NP_003347

  1. The numbers of documented pseudogenes ('pseudo'), to date, are noted in the 'Number of members' column; these numbers are likely to be gross underestimates, however, because if one does a BLAST search with each exon, numerous 'bits and pieces' of the gene plus detritus exons will probably be discovered [2].