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Table 1 Clinical details of the study population

From: Association of ADHIB and ALDH2gene polymorphisms with alcohol dependence: A pilot study from India

Population characteristic

Mean ± SD (n= 174)

ALDH2(Glu487Lys) genotype

p

  

*1/*1 (n= 128)

*1/*2 (n= 27)

*2/*2 (n= 19)

*1/*1 vs. *2/*2

Quantity of alcohol consumed (g/day)

 

200 - 400

130 - 200

30 - 50

 

Age at first use of alcohol (years)

21.2 ± 5.89

20.27 ± 6.54

20.14 ± 6.12

23.87 ± 3.833

0.067

Duration of alcohol use (years)

14.8 ± 9.36

17.00 ± 12.11

12.42 ± 3.69

12.75 ± 6.11

0.194

Duration of dependence (years)

7.53 ± 7.19

10.33 ± 8.44

6.07 ± 5.23

3.56 ± 3.31

<0.0la

Age at onset of dependence (years)

25.9 ± 8.17

22.33 ± 4.70

26.5 ± 8.27

32.06 ± 10.12

<0.0la

Duration of alcohol use prior to development of dependence (years)

7.3 ± 5.99

6.67 ± 6.99

6.36 ± 3.17

9.19 ± 6.09

0.33

SGOT (IU)

58.38 ± 63.92

66.63 ± 75.51

56.93 ± 53.38

36.12 ± 16.72

0.0lla

SGPT (IU)

47.23 ± 53.09

54.04 ± 65.60

42.18 ± 30.24

32.68 ± 20.95

0.041a

Total protein (g%)

0.62 ± 0.16

0.59 ± 0.16

0.64 ± 0.08

0.64 ± 0.22

0.45

Albumin (g%)

6.9 ± 0.71

6.88 ± 0.73

6.84 ± 0.84

7.08 ± 0.51

0.20

Bilirubin total (mg%)

4.65 ± 5.33

4.09 ± 0.49

6.88 ± 11.78

4.04 ± 0.44

0.69

  1. aSignificant at p < 0.05.
  2. SGOT, serum glutamic oxaloacetic transaminase; SGPT serum glutamic pyruvic transaminase