Table 2 Relative pharmacogenetics studies that have focused on P glycoprotein
From: Pharmacogenetics of antidepressant response: An update
Reference | Gene | Drug | Sample | Outcome measure | Results | p-value |
|---|---|---|---|---|---|---|
[16] | P glycoprotein | Various | 443 inpatients | HAMD | The following variations were associated with remission after six weeks of treatment: rs2235067 rs4148740 rs10280101 rs7787082 rs2032583 rs4148739 rs11983225 rs10248420 rs2235040 rs12720067 rs2235015 | *0.0011 0.00015 0.00029 0.0025 0.00027 0.00015 0.00022 0.0025 0.0015 0.000092 0.0024 |
[23] | P glycoprotein | Nortriptyline | 160 patients | Postural hypotension | The 3435 C > T (rs1045642) variation was associated with a higher risk of nortriptyline-induced postural hypotension. | p = 0.034 |