From: Pharmacogenetics of antidepressant response: An update
Reference | Gene | Drug | Sample | Outcome measure | Results | p-value |
---|---|---|---|---|---|---|
[24] | COMT | Bupropion | 553 smokers | Weight gain after smoking cessation | TC genotype at the C957T locus was associated with increased weight gain at six months of follow-up; however, no polymorphisms, or their interactions with bupropion, consistently and significantly predicted baseline BMI or weight change | Not significant |
[25] | COMT | Various | 346 MDD patients | HAMD | There was a small effect with citalopram treatment (Val(108/158)Met) | p = 0.007 (gene per time interaction) |
[26] | COMT | Mirtazapine and paroxetine | 102 MDD patients | HAMD | COMT polymorphism Val(108/158)Met influenced mirtazapine but not paroxetine response | p = 0.011 |