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Table 3 Relevant pharmacogenetics association studies that have focused on catechol-O-methyl transferase (COMT)

From: Pharmacogenetics of antidepressant response: An update

Reference

Gene

Drug

Sample

Outcome measure

Results

p-value

[24]

COMT

Bupropion

553 smokers

Weight gain after smoking cessation

TC genotype at the C957T locus was associated with increased weight gain at six months of follow-up; however, no polymorphisms, or their interactions with bupropion, consistently and significantly predicted baseline BMI or weight change

Not significant

[25]

COMT

Various

346 MDD patients

HAMD

There was a small effect with citalopram treatment (Val(108/158)Met)

p = 0.007 (gene per time interaction)

[26]

COMT

Mirtazapine and paroxetine

102 MDD patients

HAMD

COMT polymorphism Val(108/158)Met influenced mirtazapine but not paroxetine response

p = 0.011

  1. Abbreviations: MDD, major depressive disorder; BMI, body mass index; COMT, catechol-O-methyl transferase; HAMD, Hamilton Rating Scale for Depression