Pharmacogenetics of antidepressant response: An update

Table 7 Relevant pharmacogenetics association studies that focused on serotonin receptor 1A (5HT1A)

Reference	Gene	Drug	Sample	Outcome measure	Results	p-value
[44]	5HT1A	SSRIs	133 depressed patients	HAMD	No association	Not significant
[46]	5HT1A	Citalopram	130 depressed patients	HAMD	No association	p = 0.009
[88]	HTR1A	Fluvoxamine	151 major depressed and 111 bipolar patients	HAMD	C/C genotype (C(-1019)G) carriers showed a better response to fluvoxamine	p = 0.036
[48]	5HT1A	Fluoxetine	96 subjects with unipolar major depression	HAMD	No association	Not significant
[89]	HTR1A	Fluoxetine	222 major depressed patients	HAMD	Patients with -1019C/C genotype associated with better response	p = 0.001 (females) p = 0.007 (males)
[65]	HTR1A	Fluoxetine	224 major depressed patients	HAMD	HTRIA -1019C/C was found to be associated with a better response	p = 0.009
[20]	HTR1A	Fluvoxamine	100 depressed outpatients	HAMD	No association	Not significant

Abbreviations: SSRI, selective serotonin reuptake inhibitor; HAMD, Hamilton Rating Scale for Depression; 5HT1A and HTR1A, serotonin receptor 1A

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