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Figure 1 | Human Genomics

Figure 1

From: A biophysical mechanism may control the collinearity of Hoxdgenes during the early phase of limb development

Figure 1

Hoxd extrusions. When no positive charges are deposited opposite the 5' Hoxd subcluster, the subcluster remains inside the chromosome territory (CT). (a) For a low distribution of positive charges P (++), a small Coulomb force FI is created and one gene (Hoxd9) is extruded in the interchromosome domain (ICD). This occurs in domain D9 for cells in which the morphogen concentration is above the corresponding threshold T9. (b) For increased positive charges P (+ + + +), the force F2 is stronger and two consecutive genes (Hoxd9 and Hoxd10) are extruded. This occurs in domain D10, where the morphogen is above threshold T10.

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Human Genomics

ISSN: 1479-7364