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Figure 1S | Human Genomics

Figure 1S

From: A biophysical mechanism may control the collinearity of Hoxdgenes during the early phase of limb development

Figure 1S

Hoxd gene deletions. (a) Posterior gene deletions. Consider activation of Hoxd9 when Hoxd10 is deleted (left). N decreases and the force F is smaller than F1; therefore, Hoxd9 retreats inside the CT For the extrusion of Hoxd9, P has to increase to more posterior locations (right). (b) Anterior gene deletions. Consider activated gene Hoxd10. When anterior gene Hoxd9 is deleted, F decreases (left) but is still higher than the force F1 needed for the extrusion of the first gene (Hoxd9), hence, Hoxd10 expression shifts to more anterior cells with lower P (right)

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Human Genomics

ISSN: 1479-7364