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Table S2 Results from simulations in which the relationship between FEVand confounders was determined by published FEV prediction equations with no truncation

From: Recommendations for using standardised phenotypes in genetic association studies

N Heritability Allele frequency Power in population-based design (%) Power in family-based design (%) Avg. R2
    FEV PPFEV FEV adj. PPFEV adj. FEV PPFEV FEV adj. PPFEV adj. FEV adj. PPFEV adj.
100 0.01 0.05 6.9 15.6 17.0 16.5 5.5 9.0 9.3 9.1 84.4 6.6
   0.1 6.4 15.9 16.9 16.8 5.4 9.5 9.3 9.5 84.5 6.6
   0.2 6.6 15.7 16.6 16.5 6.0 9.7 9.6 9.6 84.4 6.8
  0.025 0.05 9.7 31.4 32.8 32.3 6.7 16.0 15.7 15.4 84.2 6.7
   0.1 9.7 32.2 34.1 33.4 7.1 16.9 17.0 16.7 84.3 6.7
   0.2 8.9 31.4 33.7 32.3 7.5 18.2 18.2 17.7 84.2 6.8
  0.05 0.05 14.6 56.2 59.3 57.2 8.7 27.0 26.8 26.0 84.0 6.8
   0.1 14.6 56.3 59.1 57.1 8.9 29.8 30.2 29.0 83.9 6.8
   0.2 14.3 57.5 60.3 58.3 10.0 31.3 31.6 30.8 83.9 6.8
400 0.01 0.05 12.2 46.9 49.5 47.3 8.2 25.4 26.2 25.3 84.1 2.1
   0.1 12.5 45.9 49.5 46.1 9.1 26.7 28.3 26.9 84.1 2.2
   0.2 12.5 47.6 50.6 47.7 8.5 27.1 27.9 26.9 84.1 2.2
  0.025 0.05 24.1 84.5 86.7 84.7 14.2 54.5 56.6 54.0 83.9 2.2
   0.1 23.6 83.7 86.3 84.1 13.8 55.9 58.4 55.8 83.9 2.2
   0.2 24.1 84.8 87.4 85.0 13.9 55.7 58.1 55.5 83.9 2.3
  0.05 0.05 43.3 98.0 99.1 98.1 23.2 80.9 82.6 80.4 83.6 2.2
   0.1 43.1 98.5 99.4 98.6 23.4 83.6 85.7 83.2 83.5 2.3
   0.2 43.0 98.7 99.3 98.8 24.3 84.4 86.8 84.0 83.5 2.4
800 0.01 0.05 20.3 73.9 77.6 74.3 12.4 46.6 48.6 46.0 84.0 1.3
   0.1 19.3 75.8 79.1 75.9 12.2 47.2 49.8 47.0 84.1 1.3
   0.2 20.0 75.6 79.0 75.8 11.9 47.0 49.4 46.6 84.0 1.3
  0.025 0.05 43.3 98.1 99.2 98.2 24.5 82.9 84.9 82.5 83.9 1.3
   0.1 42.7 98.2 99.2 98.2 23.8 84.5 86.8 84.4 83.8 1.3
   0.2 42.2 98.0 99.3 98.1 23.6 84.6 87.2 84.5 83.8 1.4
  0.05 0.05 71.0 99.6 100.0 99.6 41.9 97.7 98.7 97.6 83.5 1.3
   0.1 71.5 99.6 100.0 99.6 43.4 98.2 99.0 98.0 83.5 1.4
   0.2 71.7 99.5 100.0 99.5 42.7 98.4 99.3 98.3 83.5 1.4
  1. FEV, forced expiratory volume; PPFEV, percentage of predicted FEV.