Table S4 Results from simulations in which the relationship between FEV and confounders was determined by published FEV prediction equations and phenotype data was truncated to exclude individuals with PPFEV ≤80 percent
From: Recommendations for using standardised phenotypes in genetic association studies
N | Heritability | Allele frequency | Power in population-based design (%) | Power in family-based design (%) | Avg. R2 (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | FEV | PPFEV | FEV adj. | PPFEV adj. | FEV | PPFEV | FEV adj. | PPFEV adj. | FEV adj. | PPFEV adj. |
100 | 0.01 | 0.05 | 6.5 | 14.6 | 15.2 | 15.3 | 4.6 | 8.5 | 8.6 | 8.2 | 85.5 | 7.5 |
| Â | Â | 0.1 | 5.8 | 14.3 | 14.4 | 15.1 | 5.5 | 8.8 | 8.9 | 8.5 | 85.5 | 7.6 |
| Â | Â | 0.2 | 6.1 | 13.8 | 14.7 | 14.6 | 5.6 | 9.4 | 9.4 | 9.2 | 85.4 | 7.9 |
| Â | 0.025 | 0.05 | 8.8 | 30.4 | 31.2 | 31.5 | 5.9 | 14.3 | 14.3 | 13.9 | 85.3 | 7.7 |
| Â | Â | 0.1 | 8.4 | 29.5 | 30.5 | 30.3 | 6.6 | 15.8 | 15.8 | 15.5 | 85.3 | 7.9 |
| Â | Â | 0.2 | 7.7 | 28.5 | 29.5 | 29.4 | 6.3 | 15.7 | 15.6 | 15.1 | 85.3 | 8.0 |
| Â | 0.05 | 0.05 | 12.2 | 52.6 | 53.8 | 53.8 | 7.3 | 24.7 | 23.9 | 24.0 | 84.9 | 7.8 |
| Â | Â | 0.1 | 11.7 | 52.8 | 54.4 | 53.6 | 7.6 | 26.9 | 26.9 | 26.2 | 84.9 | 8.1 |
| Â | Â | 0.2 | 10.7 | 50.8 | 52.9 | 52.5 | 7.8 | 27.5 | 27.5 | 26.9 | 84.9 | 8.3 |
400 | 0.01 | 0.05 | 10.1 | 41.6 | 43.1 | 42.3 | 6.9 | 22.3 | 22.7 | 22.2 | 85.2 | 4.3 |
| Â | Â | 0.1 | 9.2 | 41.5 | 42.9 | 41.9 | 6.8 | 22.9 | 23.0 | 23.0 | 85.1 | 4.3 |
| Â | Â | 0.2 | 8.7 | 40.1 | 40.7 | 40.3 | 6.7 | 23.1 | 23.2 | 22.9 | 85.1 | 4.4 |
| Â | 0.025 | 0.05 | 17.3 | 79.8 | 81.8 | 80.8 | 10.4 | 48.3 | 49.1 | 48.0 | 85.0 | 4.3 |
| Â | Â | 0.1 | 16.5 | 79.8 | 81.6 | 80.5 | 10.2 | 49.1 | 50.0 | 48.7 | 85.0 | 4.5 |
| Â | Â | 0.2 | 16.6 | 78.5 | 80.0 | 78.8 | 10.2 | 48.0 | 49.4 | 47.9 | 84.9 | 4.6 |
| Â | 0.05 | 0.05 | 32.0 | 97.6 | 98.4 | 97.8 | 17.0 | 77.1 | 78.5 | 77.2 | 84.6 | 4.5 |
| Â | Â | 0.1 | 30.3 | 97.4 | 98.2 | 97.7 | 17.1 | 78.5 | 80.0 | 78.4 | 84.6 | 4.7 |
| Â | Â | 0.2 | 29.2 | 97.7 | 98.3 | 97.9 | 16.9 | 78.5 | 80.4 | 78.6 | 84.5 | 4.9 |
800 | 0.01 | 0.05 | 13.9 | 69.6 | 72.1 | 69.9 | 9.5 | 40.2 | 41.2 | 40.1 | 85.1 | 3.6 |
| Â | Â | 0.1 | 13.1 | 68.3 | 69.9 | 68.4 | 8.7 | 40.5 | 41.8 | 40.5 | 85.1 | 3.7 |
| Â | Â | 0.2 | 13.4 | 67.8 | 70.5 | 68.2 | 8.7 | 39.7 | 41.3 | 40.1 | 85.1 | 3.8 |
| Â | 0.025 | 0.05 | 30.2 | 97.1 | 97.9 | 97.3 | 16.6 | 77.3 | 79.1 | 77.6 | 84.9 | 3.7 |
| Â | Â | 0.1 | 27.7 | 97.3 | 98.1 | 97.3 | 15.5 | 78.0 | 79.7 | 78.1 | 84.9 | 3.8 |
| Â | Â | 0.2 | 26.5 | 96.8 | 97.8 | 96.8 | 15.5 | 78.4 | 80.5 | 78.7 | 84.8 | 4.0 |
| Â | 0.05 | 0.05 | 55.6 | 99.7 | 100.0 | 99.7 | 30.9 | 96.4 | 97.5 | 96.5 | 84.6 | 3.9 |
| Â | Â | 0.1 | 52.1 | 99.6 | 100.0 | 99.6 | 29.6 | 97.1 | 98.0 | 97.3 | 84.5 | 4.0 |
| Â | Â | 0.2 | 51.4 | 99.6 | 100.0 | 99.6 | 29.3 | 96.8 | 97.9 | 97.0 | 84.5 | 4.3 |