Table 3 Genomic and transcriptomic variations in annotated human AKRs
From: Aldo-keto reductase (AKR) superfamily: Genomics and annotation
AKR | Gene IDa | Chromosomal location | No. of SNPsb (in gene/coding region/non-synonymous/frameshift) | SNP frequency (per 1 kilobase: in gene/in coding region) | Peptide variants | Additional processed transcripts | Pseudogenes on vega (HGNC) |
|---|---|---|---|---|---|---|---|
1A1 | 10327 | 1p33-p32 | 154/9/5/1 | 8.01/9.2 | 3 | 10 | 0 |
1B1 | 231 | 7q35 | 160/13/9/0 | 9.53/13.67 | 3 | 12 | 5(8) |
1B10 | 57016 | 7q33 | 127/16/5/0 | 9.65/16.82 | 1 | 3 | 4 |
1C1 | 1645 | 10p15-p14 | 160/16/6/0 | 10.88/16.46 | 3 | 2 | 0 |
1C2 | 1646 | 10p15-p14 | 353/16/8/0 | 12.5/16.46 | 1 | 1 | 0 |
1C3 | 8644 | 10p15-p14 | 261/23/13/2 | 19.61/23.66 | 1 | 3 | 0 |
1C4 | 1109 | 10p15 -p14 | 198/7/6/0 | 8.95/7.2 | 1 | 1 | 0 |
1D1 | 6718 | 7q32-q33 | 275/1/0/0 | 6.57/1.02 | 4 | 2 | 2(1) |
1E2 | 83592 | 10p15.1 | 211/12/7/0 | 9.66/12.46 | 2 | 4 | 0 |
6A3 | 7881 | 3q26.1 | 1888/1/0/0 | 4.51/0.81 | 10 | 0 | 0 |
6A5 | 8514 | 1p36.3 | 414/8/2/1 | 7.15/7.25 | 8 | 6 | 0 |
6A9 | 9196 | 17p13.1 | 42/3/1/2 | 6.24/2.47 | 1 | 2 | 0 |
7A2 | 8574 | 1p36.13 | 71/10/8/0 | 8.68/9.26 | 1 | 0 | 4 |
7A3 | 22977 | 1p36.13 | 67/12/5/0 | 10.76/12.05 | 1 | 0 | 0 |