Table S1 Summary of TDT-type methods and their respective features

Curtis (1997)^S1

*

*

S-TDT (Spielman and Ewens, 1998)^S2

*

*

*

DAT (Boehnke and Langefeld, 1998)^S3

*

*

SDT (Horvath and Laird, 1998)^S4

*

*

*

NFS (Whittemore and Tu, 2000)^S5

*

*

*

*

*

TRANSMIT (Clayton, 1999)^S6

*

*

*

*

RC-TDT (Knapp, 1999)^S7

*

1-TDT (Sun et al., 1999)^S8

*

*

Martin et al. (1997)^S9

*

*

*

George et al. (1999)^S10

*

*

*

*

*

P-TDT (Abecasis et al., 2000)^S11

*

*

*

*

*

Bickeboller and Clerget-Darpoux(1995)^S12

*

Spielman and Ewens (1996)^S13

*

Purcell et al. (2005)^S14

*

*

*

TDT(max) (Morris, 1997)^S15

*

Lazzeroni and Lange (1998)^S16

*

*

Monks and Kaplan(2000)^S17

*

*

*

*

Xiong et al. (1998)^S18

*

*

Fan and Jung(2002)^S19

*

*

*

*

TDT(Q1) - TDT(Q5) (Allison, 1997)^S20,

*

*

Rabinowitz (1997)^S21

*

*

*

Allison et al. (1999)^S22

*

*

*

Sun et al. (2000)^S23

*

*

*

*

Schaid and Rowlands (2000)^S24

*

*

*

Waldman et al. (1999)^S25

*

*

Sinsheimer et al. (2000)^S26

*

*

*

*

*

Kistner and Weinberg (2004)^S27

*

*

*

QTDT (Abecasis et al., 2000)^S28

*

*

*

*

Zhu and Elston(2001)^S29

*

*

*

*

PDT (Martin, 2000)^S30

*

*

Goring and Terwilliger(2000)^S31

*

*

Clayton and Jones(1999)^S32

*

*

ETDT (Sham and Curtis, 1995)^S33

*

TDT-EX (Cleves et al., 1997)^S34

*

*

Fulker (1999)^S35

*

*

*

Fan et al. (2002)^S36

*

*

*