Genetic association tests: a method for the joint analysis of family and case-control data

Table 1 Total variance of the non-major gene component of the continuous liability underlying the binary trait and the proportion of that variance represented by each variance component for each model

		Simulated proportion of variance for each variance component
Model Name	Total variance	Polygenic	Familial	Sibling	Marital	Random
P	0.3125	0.200	- - - - - -	- - - - - -	- - - - - -	0.800
FP	0.3750	0.167	0.167	- - - - - -	- - - - - -	0.667
SP	0.3750	0.167	- - - - - -	0.167	- - - - - -	0.667
MP	0.3750	0.167	- - - - - -	- - - - - -	0.167	0.667
SMP	0.4375	0.143	- - - - - -	0.143	0.143	0.571

F = familial effect; M = marital effect; P = polygenic effect; S = sibling effect.

ISSN: 1479-7364