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Table 2 Accuracy of the association parameter as ln odds of being affected given two copies of the disease allele versus one copy for a sample size of 1,000 individuals

From: Genetic association tests: a method for the joint analysis of family and case-control data

  

Nuclear

Extended

Model*

 

RAND

ASC

RAND

ASC

FP-FP

Est

2.529

2.479

2.511

2.561

 

rMSE

0.1709

0.1210

0.1530

0.2030

FP-P

Est

2.537

2.509

2.517

2.524

 

rMSE

0.1789

0.1510

0.1591

0.1661

P-FP

Est

2.780

2.655

2.763

2.722

 

rMSE

0.1775

0.0529

0.1603

0.1196

P-P

Est

2.780

2.648

2.768

2.724

 

rMSE

0.1775

0.0458

0.1655

0.1212

  1. * Model indicates the variance components that were simulated followed by those included in the analysis model (F = familial and P = polygenic); Est is the average estimate across all replicates of that model; rMSE is the square root of the mean square error; ASC represents the analysis of an ascertained sample using ascertainment correction and RAND represents the analysis of a random sample without any such correction.
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Human Genomics

ISSN: 1479-7364